화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.87, 180-186, July, 2020
DOI10.1016/j.jiec.2020.03.041  Export Citation
Poly(propylene glycol) stabilized gold nanoparticles: An efficient colorimetric assay for ceftriaxone
Daim Asif Raja1, Syed Ghulam Musharraf1, Muhammad Raza Shah1, Abdul Jabbar1, 2, Muhammad Iqbal Bhanger1, and Muhammad Imran Malik1, †
  • 1H.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi 75270, Pakistan
  • 2Textile Institute of Pakistan, Karachi, Pakistan
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Polymer capped metal nanoparticles have been used for numerous biomedical and analytical applications. In present study, highly stable gold nanoparticles (AuNPs) capped with polypropylene glycol (PPG) were synthesized using chemical reduction method. The characterization of PPG-AuNPs was accomplished by atomic force microscopy (AFM), zetasizer, fourier transform infrared spectroscopy (FT- IR) and UV-vis spectroscopy. Furthermore, PPG-AuNPs were utilized as colorimetric probe for third generation cephalosporin antibiotic, ceftriaxone (CEF). PPG-AuNPs permitted efficient, selective, quantitative and rapid recognition in concentration range of 0.1.100 μM in presence of numerous other drugs and salts. PPG-AuNPs have great potential for quantitative recognition of ceftriaxone in biological and environmental samples. Moreover, the developed sensor has capacity to be applied as quality control of pharmaceutical formulations containing ceftriaxone. The PPG-AuNPs based sensor permits quantitative and fast recognition of ceftriaxone away from a sophisticated laboratory setup.
Keywords:PPG-AuNPs;Colorimetric assay;Ceftriaxone;Sensor;Cephalosporin antibiotic
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