In the present work, double-pass indirect solar dryer (DPISD) and double-pass indirect solar dryer with mesh absorber modification (DPISDMA) have been designed, analyzed, manufactured and tested. The main aim of this study is improving the thermal efficiency of double-pass solar air collector by integrating iron meshes. Pepino fruit (Solarium muricatum L.) samples in two thicknesses have been used in the experimental study. Also, CFD analysis of both solar air collectors and drying chamber and quality metrics such as phenolic, total flavonoid contents and antioxidant activity have been conducted. Numerical simulation and experimental results showed that using mesh modification has positive influence on the performance of the collector. The highest value of the average efficiency of the dryer was obtained in DPISDMA for the thin sample thickness as 23.08%. According to quality analyses, the experiments which done in DPISDMA gave the best results with highest values of TPC, TFC and antioxidant activity values (p < 0.05). Drying data of the pepino fruit for different experiments were modelled according to 8 different most used mathematical models. Accordingly, the best fitted kinetics model was determined as Logarithmic model for all experiments which gave the most accurate statistical values.