The thiophene extraction from model fuel by using N-methyl-2-pyrrolidone [NMP], dimethylformamide [DMF] and ethylene glycol [EG] as solvents had been carried out at atmospheric pressure. It is found that NMP showed the best performance with 98% removal of thiophene for 1 h. A detail parametric study was performed to investigate the effect of different process parameters on the extraction of thiophene by using NMP as the solvent. Finally Box-Behnken design (BBD) explores the relationship between output, sulfur removal efficiency and inputs parameters like time, temperature and solvent to model fuel volume ratio.