In this work we present a multiscale approach for coupling the dynamics of void collapse at the microscale to simulations at the mesoscale. We solve the reactive Euler equations, with the energy equation augmented by a power deposition term. The reaction rate at the mesoscale is modelled using a pressure-dependent power law. The deposition term is based on previous simulations of void collapse, modelled at the mesoscale as hot-spots. The equation of state was previously calibrated for PBX 9501. The run-to-detonation distance is calculated as part of the numerical solution procedure. Results for 1-D, 2-D homogeneous, and 2-D heterogeneous medium are presented, and show good agreement to experimental data.