The additive and antagonistic effects of the substrates and vapors on morphology of glycyl-glycine film were observed. The direction of joint effect significantly depends on the ability of the organic compound to form hydrogen bond. The vapors of strong H-donor or H-acceptor are able to overcome the interaction of the dipeptide molecules with substrate and change the film morphology. The Hansen solubility parameters can be used to predict the ability of vapors to initiate the self-assembly of dipeptide in solid state. The possible mechanism of glycyl-glycine self-assembly in solid state was proposed. [GRAPHICS]