In this paper a new observer is introduced to estimate the Crystal Size Distribution (CSD) only from the measurements of the solute concentration, temperature and a model of the growth rate. No model of the nucleation rate is needed. This approach is based on the use of a Kazantzis-Kravaris/Luenberger observer which exponentially estimates functionals of the CSD. Then, the full state is estimated by means of a Tikhonov regularization procedure. Numerical simulations are provided. Our approach relies on an infinite-dimensional observer, contrarily to the usual moment based observers. (C) 2020 Elsevier Ltd. All rights reserved.