Experimental solubility data of D-ribose in four binary (2-propanol + 1-hexane, ethanol + 1-hexane, methanol + dichloromethane, and ethanol + dichloromethane) and twelve pure (1-hexane, dichloromethane, ethyl acetate, acetonitrile, acetone, 2-methyl-1-propanol, 1-butanol, 2-propanol, 2-butanol, 1-propanol, ethanol, and methanol) solvent systems were measured at different temperatures under the atmospheric pressure by using the gravimetric method. The experimental results showed that the solubility of D-ribose increased with the increase of temperature and the content of positive solvent, and decreased with the increase of antisolvent composition. The dissolution behavior of D-ribose in pure solvents was mainly affected by the solvent types and solvent properties, and the solvent effect on D-ribose solubility was further examined by the KAT-LSER model. The solubility data were correlated by the modified Apelblat, Jouyban-Acree, and Apelblat-Jouyban-Acree models. The calculated values of the three thermodynamic models were in good agreement with the experimental data.