The solubility of trehalose dihydrate in water + isopropanol/1-propanol/tert-butanol with the mole fraction of water ranging from 0.2 to 0.8 at temperatures from 283.15 to 328.15 K was measured by a static gravimetric method. The oiling out phenomenon was found during solubility measurement at a high mole fraction of water in a binary solvent. The solubility data in the experiment were well correlated with the Jouyban-Acree model.