This work presents the H-2 production from methanol steam reforming (MSR) process by thermodynamic equilibrium analysis using the Gibbs free energy minimization method and multi-factor coupling method. To determine desirable procedure parameters with maximum methanol conversion and H-2 content and minimum CO content, the impacts of the temperature: 100-400 degrees C, steam-to-methanol (S/C) molar ratio: 1.0-3.0, and pressure: 0.5-3.0 atm were investigated. The dominant factor under the action of multiple factors and the specific influence of each factor on the MSR process were verified, simultaneously. For proton exchange membrane fuel cell (PEMFC), to keep the CO content of the reformate within a desired range, and under the premise of complete methanol conversion, the MSR process can be operated at lower temperature, higher S/C ratio and atmospheric pressure. Combined with practice process, the optimum values of the temperature, S/C ratio and pressure to produce reformate were identified to be 200-300 degrees C,1.6-2.0 and 1.0 atm, respectively. (C) 2020 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.