The MoS2 quantum dots (QDs) were interspersed on anatase TiO2 nanosheets with exposed (001) facets by a facile self-assembly strategy. As expected, the MoS2 QDs/TiO2 nanosheets display an excellent photocatalytic performance for hydrogen production, and its hydrogen evolution rate is 139 mu mol/h/g. More importantly, the hydrogen evolution rate of MoS2 QDs/TiO2 nanosheets is almost 4-fold in comparison to that of nude TiO2 nanosheets. Based on the detailed characterizations, it can be obtained that the improved photocatalytic activity for hydrogen production can be ascribed to the particular characteristics of MoS2 QDs, which can intensify the photo-absorption efficiency of TiO2 nanosheets and enhance the separation and transfer efficiency of photo-excited charge carriers. It is anticipated that this work provides a novel paradigm to fabricate the highly-efficient photocatalysts for hydrogen evolution.