This paper is concerned with the fault detection problem for a class of networked multi-rate systems with nonuniform sampling and dynamic quantization. The sampling interval of the measurements is allowed to be nonuniform that is governed by a time-homogenous Markov process with partly unknown and uncertain transition probabilities. The measured output is quantized by a dynamic quantizer and then transmitted through communication network subject to data missing. The main purpose of the problem under consideration is to design sampling-interval-dependent fault detection filters such that, in the simultaneous presence of nonuniform sampling, dynamic quantization, intermittent faults as well as missing measurements, the robustness of residuals with respect to the disturbance and the sensitivity of the residuals against the fault are guaranteed. Finally, a three-tank system is utilized to illustrate the effectiveness of the proposed fault detection scheme.