This study examines the general applicability of magnetic seeded filtration (MFS) for the fractionation of complex particulate systems by multiple particle features. Experimental studies on a laboratory scale showed that especially the electrostatic interactions govern the separation process. Furthermore, a clear size dependency could be shown, as the separation efficiency decreases with increasing size of target particles. Since MSF is both surface- and size-dependent, it is generally applicable in a multidimensional fractionation. Finally, the challenges to be overcome are addressed as well.