The potential of squalene recovery from oil deodorizer distillates (ODD) via a combination of supercritical ethanol esterification, supercritical CO2-extraction and additional purification was assessed via detailed process simulations. The squalene yields and purity from olive, sunflower and soybean ODD were determined. The highest squalene yield and purity could be achieved starting from olive ODD (95 g(squalene) kg(-1) ODD, 99 wt% pure), followed by soybean ODD (31 &quo. kg-lorm, 98 wt% pure) and sunflower ODD (24 g(squalence) kg(-1) ODD, 98 wt% pure). Apart from squalene, two more value-added products can be produced, i.e., high purity ethyl esters (>88 wt%) and a mixture of tocopherols and sterols. On a scale of 1 kTonneoco per year, all feedstocks demonstrate economical potential in Europe. Even more, a flexible process configuration could be designed which is suitable for the treatment of the different feedstocks. (C) 2019 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.