The hydrothermal characteristics of minichannel heat sink are analyzed experimentally by using deionized (DI) water based different nanoparticles mixture dispersed hybrid nanofluids. Al2O3, MgO, SiC, AlN, MWCNT and Cu nanoparticles are considered for this study. Different nanoparticles combinations (oxide-oxide, oxide-carbide, oxide-nitride, oxide-carbon nanotube and oxide-metal) in 50/50 vol ratio with base fluid (DI water) have been taken as coolants for volume concentration of 0.01%. Effects of volume flow rate (0.1-0.5LPM), fluid inlet temperature (20-40 degrees C) and Reynolds number (50-500) are studied for heat flux of 50 W/cm(2). Convective heat transfer coefficient and pressure drop are increased by about 42.24% and 22% for Al2O3 + MWCNT hybrid nanofluid. The maximum reduction of 21.36% in thermal resistance is obtained for Al2O3 + MWCNT hybrid nanofluid in comparison to DI water. Heat transfer effectiveness and figure of merit are above one for all the hybrid nanofluids which conclude that hybrid nanofluid is better option for electronics cooling over DI water. Al2O3 + MWCNT hybrid nanofluid is better in terms of heat transfer effectiveness; whereas, Al2O3 + AlN hybrid nanofluid (oxide-nitrite mixture) has maximum heat transfer coefficient to pressure drop ratio and coefficient of performance. (C) 2019 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.