화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.28, No.4, 310-318, April, 2020
DOI10.1007/s13233-020-8005-4  Export Citation
Preparation and Characterization of Poly(ethylene glycol)-block-Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-block-Poly(ethylene glycol) Triblock Copolymers
Liujun Shi, Wei Hu, Yongjin He, Yu Ke1, †, Gang Wu2, Meng Xiao3, Langhuan Huang, and Shaozao Tan†
  • Guangdong Engineering & Technology Research Centre of Graphene-Like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, P. R. China
  • 1Department of Biomedical Engineering, Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou 510632, P. R. China
  • 2Department of Biomedical Engineering, South China University of Technology, Guangzhou 510641, P. R. China
  • 3Department of Materials Science and Engineering, School of Chemistry and Materials, Jinan University, Guangzhou 510632, P. R. China
E-mail:,
Amphiphilic triblock copolymers, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) as a hydrophobic block and poly(ethylene glycol) (PEG) as a hydrophilic block, were successfully synthesized, with an aim to broaden the potential application of PHBV in biomedical areas. Isophorone diisocyanate having two different reactive isocyanate groups was used as the coupling agent. Telechelic hydroxylated PHBV was prepared by alcoholysis reaction, isocyanate modified and finally reacted with PEG. Molecular weight of triblock copolymer increased with the increasing molecular weight of PHBV-diol and PEG. The length of the PHBV block and PEG block had a great influence on the crystallization behavior of the triblock copolymers. Thermal degradation temperature of PHBV segment enhanced greatly. The triblock copolymer showed a tendency toward formation of aggregation in aqueous solution with a critical aggregation concentration of 5.01×10-4 g·L-1, and the rod-shape assembly with a uniform hydrophilic shell might be employed as hydrophobic drug delivery systems.
Keywords:PHBV;PEG;block copolymer;critical aggregation concentration
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