A previously reported ion-exchange/extraction chromatographic scheme for the recovery of radiostrontium from urine for subsequent determination is systematically optimized to minimize reagent consumption, enhance system reusability, and maximize sample throughput. In addition, a preliminary assessment of the effect of mobile phase flow rate on strontium uptake is described. The results show that the tandem system can be re-used without loss of performance, and that the rate at which samples can be processed by the system is ultimately limited by the time required for regeneration of the ion-exchange column and the kinetics of metal ion uptake on the extraction chromatographic sorbent.