This work aims to develop a method for producing a-mangostin that has high bio-accessibility through the use of supercritical carbon dioxide (scCO(2)) extraction of mangosteen pericarp extract (MPE) with virgin coconut oil (VCO) as co-extractant. Extractions with scCO(2) were carried out at 30 MPa to 40 MPa, 60 degrees C, CO2 flow rate of 1.7 g/min and co-extractant VCO (0% to 20%). MPE yield and extraction yield increased with the amount of co-extractant added. The highest yield of MPE obtained was 17% at conditions of 35 MPa with 20% of VCO. The scCO(2) MPE had higher bio-accessibility for a-mangostin (91%) than a-mangostin obtained by extraction with ethanol (30%) or hexane (50%). Thus, supercritical CO2 extraction used with virgin coconut oil co-extractant provides a method for producing high bio-accessible alpha-mangostin from mangosteen pericarp extract.