The solubility profiles of sancycline in methanol, ethanol, n-propanol, isopropanol, 1-butanol, isobutyl alcohol, n-octanol, cyclohexane, n-hexane, acetonitrile, ethyl acetate, and 1,4-dioxane were determined experimentally by using the isothermal dissolution equilibrium method at the temperature range from 278.15 to 318.15 K under a pressure of 101.2 kPa. As expected, the solubility data in mole fraction increased with the rising temperature. The maximum solubility value was obtained in 1,4-dioxane (3.364 X 10(-3) at 318.15 K), and the lowest was in cyclohexane (8.979 X 10(-5) at 318.15 K). At all researched temperature, solubility profiles are presented from high to low in the following order: 1,4-dioxane > ethyl acetate > methanol > ethanol > acetonitrile > n-propanol > 1-butanol > isopropanol > isobutyl alcohol > n-hexane > n-octanol > cyclohexane. Moreover, the effect of intermolecular force between solvent and solute on solubility was analyzed, especially in alcoholic solvents. In addition, these solubility values in different solvents were correlated by the modified Apelblat equation and lambda h equation. For the modified Apelblat equation, the largest RAD value is 1.05%, and for the lambda h equation, the largest RAD value is 3.10%. Because the results of the two equations are quite different from the experimental values, further residual analysis of the data shows that the correlation result of the modified Apelblat equation is slightly better than that of the lambda h equation.