Cofactor (reduced) Nicotinamide Adenine Dinucleotide (NAD(P)H) is an energy carrier in enzymatic redox reactions that are employed for the synthesis of valuable chemicals and pharmaceuticals. The high cost of NAD(P) H makes it impractical to use in stoichiometric amounts in industrial processes. This has led to the development of a variety of methods for NAD(P)H regeneration. In this work, process cleanliness of the current NADH recycling systems was evaluated using E-factor (kg(waste)/kg(NADH)) as a green chemistry metric. The E-factor obtained, depending on the process method, reaches values higher than 20000, where non-recyclable agents, including sacrificial hydride/electron donors, catalysts and electron mediators, alongside by-products (from cosubstrates), account for the overall waste. A promising alternative methodology for NADH regeneration using H-2 and recyclable Pt/Fe3O4 is presented and characterisation performed by temperature-programmed reduction (TPR), nitrogen adsorption (surface area/porosity), powder X-ray diffraction (XRD) and transmission electron microscopy (TEM) is used to elucidate the observed performance. The Pt/Fe3O4 system at room temperature delivers a turnover frequency of 20 h(-1) and the catalyst can be recycled for reuse, producing a significantly low level of waste (E-factor = similar to 1).