화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.28, No.1, 23-32, January, 2020
DOI10.1007/s13233-020-8009-0  Export Citation
Improvement of Biodegradability and Biocompatibility of Electrospun Scaffolds of Poly(butylene terephthalate) by Incorporation of Sebacate Units
Nina Heidarzadeh1, Luis J. del Valle2, 3, †, Lourdes Franco2, 3, and Jordi Puiggalí2, 3, †
  • 1Department of Chemical Engineering, Dupuis Hall, Queen’s University, Kingston, Ontario K7L 3N6, Canada
  • 2Chemical Engineering Department, Escola d'Enginyeria de Barcelona Est-EEBE, Av. Eduard Maristany 10-14, Barcelona 08019, Spain
  • 3Escola d'Enginyeria de Barcelona Est-EEBE, Barcelona Research Center for Multiscale Science and Engineering. Universitat Politècnica de, Av. Eduard Maristany 10-14, Barcelona 08019, Spain
E-mail:,
Incorporation of aliphatic units to poly(butylene terephthalate) (PBT) gives rise to biodegradable copolymers with tunable properties (e.g., degradability), depending on the selected comonomer and the specific composition. Specifically, a low molecular weight poly(butylene sebacate-co-terephthalate) (PBSeT) with a high ratio of aliphatic sebacate units (i.e., 70 mol-% with respect to the total dicarboxylate content) has been employed in this work to get new electrospun biodegradable scaffolds. Appropriate electrospinning conditions have been found despite the limited copolymer molecular weight. In addition, PBSeT has been employed to improve biocompatibility and biodegradability of scaffolds based on the PBT homopolymer. Scaffolds with different properties have been prepared following two strategies: Electrospinning of single solutions of PBT and PBSeT mixtures and co-electrospinning of independent PBT and PBSeT solutions. Characterization involved spectroscopic (FTIR, NMR), calorimetric (DSC, TGA) and surface hydrophobicity analyses. Hydrolytic and enzymatic degradation studies demonstrated the success of the approach due to the susceptibility of the PBSeT component towards the enzymatic attack with lipases from Pseudomonas cepacia and even towards high temperature hydrolysis.
Keywords:poly(butylene terephthalate);poly(butylene sebacate);aliphatic/aromatic copolymers;electrospinning;biodegradability;biocompatibility
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