3D-Printed Poly Lactic Acid Scaffolds with Tetrapod-Interlocked Structure Containing Dipyridamole

Dae-Ryong Jun; Guk-Young Ahn; In Seong Choi; Tae Hoon Yun; Kun Na; Sung-Wook Choi

Macromolecular Research, Vol.28, No.1, 5-8, January, 2020

DOI10.1007/s13233-020-8017-0 Export Citation

3D-Printed Poly Lactic Acid Scaffolds with Tetrapod-Interlocked Structure Containing Dipyridamole

Dae-Ryong Jun, Guk-Young Ahn, In Seong Choi, Tae Hoon Yun, Kun Na, and Sung-Wook Choi^†

Department of Biotechnology, The Catholic University of Korea, Gyeonggi 14662, Korea

E-mail:

Poly lactic acid (PLA) filament containing dipyridamole (DIP) was prepared and DIP/PLA tetrapod-interlocked scaffold was printed by fused deposition modeling method. Tetrapod-interlocked structure was designed with CAD and translated into G-code with slic3r program. The mechanical property was investigated using universal testing machine. Compressive stress resistance of the tetrapod-interlocked structure was significantly increased. Meanwhile, release profile and osteoblast proliferation ability of tetrapod-interlocked scaffold with DIP was examined. Osteoblast proliferation was increased with the increasing amount of DIP.

Keywords:3D-printing;tetrapod;scaffold;dipyridamole

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[2] El-Hajje A, Kolos EC, Wang JK, Maleksaeedi S, He Z, Wiria FE, Choong C, Ruys AJ, J. Mater. Sci. -Mater. Med., 25, 2471 (2014)

[3] Temple JP, Hutton DL, Hung BP, Huri PY, Cook CA, Kondragunta R, Jia X, Grayson WL, J. Biomed. Mater. Res. A, 102, 4317 (2014)

[4] Wang X, Rijff BL, Khang G, J. Tissue. Eng. Regen. Med., 11, 1403 (2017)

[5] Rutz AL, Hyland KE, Jakus AE, Burghardt WR, Shah RN, Adv. Mater., 27(9), 1607 (2015)

[6] Ciocca L, De Crescenzio F, Fantini M, Scotti R, Comput. Med. Imag. Grap., 33, 58 (2009)

[7] Diomede F, Gugliandolo A, Cardelli P, Merciaro I, Ettorre V, Traini T, Bedini R, Scionti D, Bramanti A, Nanci A, Caputi S, Fontana A, Mazzon E, Trubiani O, Stem Cell Res. Ther., 9, 104 (2018)

[8] Kim JY, Ahn G. Kim C, Lee JS, Lee IG, An SH, Yun WS, Kim SY, Shim JH, Macromol. Biosci., 18, 180002 (2018)

[9] Kim HW, Lee SY, Bae CJ, Noh YJ, Kim HE, Kim HM, Ko JS, Biomaterials, 24, 3277 (2003)

[10] Zhang B, Pei X, Zhou C, Fan Y, Jiang Q, Ronca A, D'Amora U, Chen Y, Li H, Sun Y, Zhang X, Mater. Des., 152, 30 (2018)

[11] Sansone V, Pagani D, Melato M, Clin. Cases Miner. Bone Metab., 10, 34 (2013)

[12] Vestergaard P, Steinberg TH, Schwarz P, Jørgensen NR, Int. J. Cardiol., 160, 36 (2012)

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[14] Mediero A, Wilder T, Perez-Aso M, Cronstein BN, Faseb J., 29, 1577 (2015)