The aim of this study was to develop a modified release system (MRS), hydrophilic matrix type, containing Physalis peruviana fruit extract as the active ingredient. For this purpose, a co-processing method via spraydrying was used, whose conditions were previously established, using in the formulation silicon dioxide as a drying aid and HPMC K15M as a polymer, to modulate the release of the extract. Four formulations were prepared, and pharmacotecnical properties and hypoglycemic in vitro assay were evaluated; in these formulations, the ratio of the polymer was changed to find the influence of this excipient on the release of the extract, from the hydrophilic matrices, under different pH conditions simulating the gastrointestinal tract. To selected formulation from this test, other assays were performed such as erosion studies, water uptake and movement fronts, which complemented the evaluation on the release mechanism. It was established that composition of the coprocessed with and without polymer, presented good flow and compaction properties. The characterization of the MRS showed a modulated release of the extract, the concentration of the polymer was the main factor that affected its release rate. Formulation Ex: SiO2: HPMC-K15M (55.2%: 41.4%: 3.4%) was selected, among the formulations evaluated, because it presented adequate modulation of the extract release. The release mechanism was a combination of diffusion of the extract and erosion of the matrix. The in-vitro studies showed that the excipients and the process did not significantly influence the hypoglycemiant activity of the extract. (C) 2019 Elsevier B.V. All rights reserved.