The sliding behavior of anisotropic surfaces is a crucial property to their applications from fundamental research to practical fields. Herein, we propose a theoretical model for analyzing the sliding behavior based on the concept of adhesion energy. Surface Evolver simulation is conducted to determine the adhesion energy per unit area. The microgrooved surfaces are fabricated and characterized to validate the proposed theory. It is found that the apparent contact angle measured along the direction parallel to the strips increases with the increase of microgroove width, while the corresponding sliding angles exhibit an opposite trend. The adhesion energy per unit area has a constant value regardless of the droplet volume. The different sliding behaviors of anisotropic surfaces along the perpendicular and parallel directions are attributed to the difference in the corresponding adhesion energies per unit area. The proposed model is expected to be used for predicting the sliding behavior of anisotropic surfaces.