Journal of the American Chemical Society, Vol.119, No.30, 6974-6979, 1997
Divalent, Trivalent, and Tetravalent Dendritic Galabiosides That Inhibit Hemagglutination by Streptococcus-Suis at Nanomolar Concentration
Galabiose (Gal alpha 1-4Gal) derivatives were coupled to carrier molecules having mono-, di-, tri-, and tetrameric functionalities, thus creating mono- to tetravalent dendritic galabiosides (1-9). The di- to tetravalent galabiosides were several hundred times more efficient than the monomeric galabiosides in inhibiting hemagglutination by the Gram-positive bacterium Streptococcus suis, resulting in complete inhibition at low nanomolar concentrations. This is unprecedented in the field of inhibition of bacterial adhesion by soluble compounds.
Keywords:UROPATHOGENIC ESCHERICHIA-COLI;OLIGOSACCHARIDE SEQUENCES;COMBINING SITE;RECEPTOR;GLYCOSIDES;ANALOGS;TRISACCHARIDE;RECOGNITION;SPECIFICITY;ADHESIN