The interconnecred PtIr alloy nanowires were uniformly deposited on carbon cloth via One-step wet chemistry method, which diameter is averaged to be 5 nm with a length of 50-200 nm. The carbon cloth supported PtIr nanowire assembly (Ptlr NA/CC) shows a larger electrochemical active surface area (ECSA) due to its 3D nanostructure and a high CO-resistance as a result from the synergistic effect of PtIr alloy. The PtIr NA/CC exhibits an extremely high mass activity and a reliable long-term stability toward methanol oxidation reaction (MOR). The superior catalytic performance on MOR can match and even surpass those best Pt-based nanowires reported recently in the literature. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.