The kinetic of Fischer-Tropsch reaction was investigated using the iron-nickel-cerium nano-structure catalyst synthesized by the hydrothermal method in the fixed-bed micro reactor for the first time. The kinetic tests carried out under operating conditions including the pressure of 2-10 bar, temperature of 230-250 degrees C, molar ratio H-2/CO of 1, and the gas space velocity of 3000 h(-1). Twenty-two set of reaction mechanisms were proposed on the basis of the adsorption nature of carbon monoxide, and hydrogen using the Langmuir- Hinshelwood-Hougen-Watson, and Eley Rideal adsorption theories for the FT reaction. The rate equations of CO consumption were obtained based on the proposed reaction mechanisms. The best kinetic model was chosen by non-linear regression analysis and its kinetic parameters including activation energy, adsorption enthalpies of H-2, and CO were estimated 60.4, -3.24, and -65.7 kJ/mol respectively. The nanocatalyst was characterized by various techniques such as XRD, FESEM, and Brunauer-Emmett-Teller surface area measurements. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.