The integration of supercritical CO2 (SCO2) cycle instead of steam Rankine cycle may be a revolutionary technique to increase the efficiency of coal-fired power plants. To effectively extract exergy from the fluegas and convert exergy to power, the characteristics of hot end (heat reservoir) and cold end (heat sink) should be fully considered, and the system multi-parameters should be optimized. In this study, based on a benchmark coal-fired power plant integrated with a recompression SCO2 power cycle, quantitative efficiency enhancements of system improvements of the hot end and cold end for SCO2 power cycle are calculated and compared. The optimized efficiency of benchmark coal-fired plant integrated with recompression SCO2 power cycle is 45.43%. When the fluegas at the economizer outlet is effectively used, the power plant efficiency can be increased by 1.32%. With single and double reheats to decrease the heat transfer irreversibility of the hot end, the power plant efficiency can be increased by 1.77% and 2.24%, respectively. Cold end optimization with single intercooling and cold air preheating can increase the power plant efficiency by 0.32% and 0.33%, respectively. Finally, a simple structure system and a complex structure system are proposed. With optimal system parameters, the power plant efficiencies of the complex and simple systems are 49.320/0 and 48.52%, respectively.