This paper presents an analysis of single-stage scroll expander performance for pure fluids and their zeotropic mixtures in supercritical conditions using dimensionless parameters, namely specific speed (N-s) and specific diameter (D-s). Scroll geometries with different aspect ratios were modeled for a range of expander inlet temperatures. The expander efficiency was modeled accounting for losses due to leakage, friction, and over- and under-expansion. The expander efficiency was plotted as a function of two dimensionless parameters to analyze the applicability domain of scroll expanders. For a particular expander inlet temperature (T-in), zeotropic mixtures result in more compact scroll geometries than pure fluids, leading to reduced losses and better expander efficiency. Any increase in T-in results in larger scrolls leading to higher leakage and thereby lower efficiency. At suitable operating conditions, an optimized scroll expander design can achieve expansion efficiency as high as 75%. Sub-optimal scroll designs for a given application lead to lower expansion efficiency due to over- or under-expansion losses. (C) 2019 Elsevier Ltd. All rights reserved.