Dolastatins .26. Synthesis and Stereochemistry of Dolastatin-11

Bates RB; Brusoe KG; Burns JJ; Caldera S; Cui W; Gangwar S; Gramme MR; Mcclure KJ; Rouen GP; Schadow H; Stessman CC; Taylor SR; Vu VH; Yarick GV; Zhang JX; Pettit GR; Bontems R

Journal of the American Chemical Society, Vol.119, No.9, 2111-2113, 1997

Bates RB, Brusoe KG, Burns JJ, Caldera S, Cui W, Gangwar S, Gramme MR, Mcclure KJ, Rouen GP, Schadow H, Stessman CC, Taylor SR, Vu VH, Yarick GV, Zhang JX, Pettit GR, Bontems R

The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural product and in dolastatin 12, majusculamide C, and 57-normajusculamide C.

Keywords:CYCLIC DEPSIPEPTIDE;LYNGBYA-MAJUSCULA;COUPLING REAGENT;ACIDS;57-NORMAJUSCULAMIDE-C