Evidence is provided that stable operation of a microstructured reactor for steam-assisted catalytic partial oxidation (sCPOX) and its subsequent coupling with a Fischer-Tropsch synthesis (FTS) reactor is possible at pressures up to 25 bar. The product composition of the sCPOX was determined and subsequently used as feed composition for a downstream FTS reactor to prove the possibility of coupling with syngas generation. After stable operation was proven in both setups, they were coupled and operated together, feeding the product gas stream of the sCPOX to the FTS. In addition, the negative influence of sulfur in the sCPOX-gas feed was evaluated.