Fabrication and Evaluation of Polyelectrolyte Complexes of Dextran Derivatives for Drug Coating of Coronary Stents

Eun-Jae Jang; So-Youn Lee; In-Ho Bae; Dae Sung Park; Myung Ho Jeong; Jun-Kyu Park

Applied Chemistry for Engineering, Vol.30, No.5, 586-590, October, 2019

DOI10.14478/ace.2019.1057 Export Citation

Fabrication and Evaluation of Polyelectrolyte Complexes of Dextran Derivatives for Drug Coating of Coronary Stents

Eun-Jae Jang^{1, 2}, So-Youn Lee^{2, 3}, In-Ho Bae^{2, 3}, Dae Sung Park^{2, 3}, Myung Ho Jeong^{4, †}, and Jun-Kyu Park^{5, †}

¹Biopharmaceutical Research Center, Hwasun 58141, Korea
²Hospital Designated by Ministry of Health and Welfare, The Cardiovascular Convergence Research Center of Chonnam National University, Gwangju 61469, Korea
³Korea Cardiovascular Stent Research Institute, Jangsung 57248, Korea
⁴Department of Cardiology, Chonnam National University Hospital, Gwangju 61469, Korea
⁵CGBio Co. Ltd, Jeonnam 57248, Korea

E-mail:,

The aim of this study was to fabricate a dextran polyelectrolyte multi-layer on a bare metal stent (BMS) and to evaluate bio-physical properties of the layer. Diethylaminoethyl-dextran (DEAE-D) as a polycation and dextran sulfate (DS) as a polyanion were successively coated on the bare metal stent by a well-known layer-by-layer procedure. The morphology of the stent surface and its cell adhesion were studied after each coating step by scanning electron microscopy. The stent showed more blotched and slightly rougher morphology after dextran-DS coating. The contact angle of the DEAE-DS group (39.5 ± 0.15°) was significantly higher than that of the BMS group (45.16 ± 0.08°), indicating the improvement of hydrophilic. The SMC proliferation inhibition in the DEAE-DS-coated stent group (20.9 ± 0.04%) was stronger than that in the control group (21.7 ± 0.10% in DS-coated group only). The DEAE-DS coating is desired for stent coating materials with biocompatibility and anti-restenosis effect.

Keywords:Dual drug-eluting stent;Electrolyte coating;Dextran;Nature polymer;Anti-restenosis

[References]

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Ganji F, Vasheghani-Farahani E, Iran. Polym. J., 18, 63 (2009)
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[Referenced By]

[1] Tsimikas S, J. Am. Coll. Cardiol., 47, 2112 (2006)

[2] Jeong GW, Kim TH, Nah JW, Park JK, Appl. Chem. Eng., 29, 5, 497-502.

[3] Welt FG, Rogers C, Arterioscler. Thromb. Vasc. Biol., 22, 1769 (2002)

[4] Spaulding C, Daemen J, Boersma E, Cutlip DE, Serruys PW, N. Engl. J. Med., 356, 989 (2007)

[5] Meng S, Liu Z, Shen L, Guo Z, Chou LL, Zhong W, Biomaterials, 30, 2276 (2009)

[6] McFadden EP, Stabile E, Regar E, Cheneau E, Ong AT, Kinnaird T, Lancet, 364, 1519 (2004)

[7] Guan C, Xu B, Qiao S, Qin L, Li Y, Li Z, Guo Y, Sun Z, Song L, Gao R, Catheter. Cardiovasc. Interv., 89, 520 (2017)

[8] Han Y, Xu B, Xu K, Guan C, Jing Q, Zheng Q, Li X, et al., Circ. Cardiovasc. Interv., 9, e00314 (2016)

[9] Bae IH, Jeong MH, Kim JH, Park YH, Lim KS, Park DS, Shim JW, Ahn Y, Hong YJ, Sim DS, Korean Circ J., 47, 123 (2017)

[10] Sethi A, Bahekar A, Bhuriya R, Bajaj A, Singh PP, Arora R, Khosla S, Arch. Cardiovasc. Dis., 105, 544 (2012)

[11] Aoki J, Intern. Med., 54, 549 (2015)

[12] Yazdani SK, Vorpahl M, Nakano M, Su SH, Kolodgie FD, Virmani R, EuroIntervention, 7, 835 (2011)

[13] Thierry B, Winnik FM, Merhi Y, Silver J, Tabrizian M, Biomacromolecules, 4(6), 1564 (2003)

[14] Sun G, Shen YI, Kusuma S, Fox-Talbot K, Steenbergen CJ, Gerecht S, Biomaterials, 32, 95 (2011)

[15] Van Tomme SR, Hennink WE, Expert Rev. Med. Devices, 4, 147 (2007)

[16] Lin WC, Yu DG, Yang MC, Colloids Surf. B: Biointerfaces, 44, 82 (2005)

[17] Chung AJ, Rubner MF, Langmuir, 18, 1176 (2005)

[18] Groth T, Lendlein A, Angew. Chem.-Int. Edit., 43, 926 (2004)

[19] Zhang J, Senger B, Vautier D, Picart C, Schaaf P, Voegel JC, Lavalle P, Biomaterials, 26, 3353 (2005)

[20] Bae IH, Lim KS, Park JK, Park DS, Lee SY, Jang EJ, Ji MS, Sim DS, Hong YJ, Ahn Y, Park JC, Cho JG, Kang JC, Kim IS, Nah JW, Jeong MH, J. Ind. Eng. Chem., 21, 1295 (2015)

[21] Lim KS, Bae IH, Kim JH, Park DS, Kim JM, Kim JH, Chonnam Med. J., 49, 7 (2013)

[22] Buszman P, Trznadel S, Zurakowski A, Milewski K, Kinasz L, Krol M, Kardiologia Polska, 65, 1041 (2007)

[23] Benni S, Avramoglou T, Hlawaty H, Mora1 Y, Biomed Res. Int., 10, 679031 (2014)

[24] Ganji F, Vasheghani-Farahani E, Iran. Polym. J., 18, 63 (2009)

[25] Costamagna G, Mutignani M, Rotondano G, Cipolletta L, Ghezzo L, Foco A, Zambelli A, Gastroint. Endosc, 51, 8 (2000)

[26] Leung JW, Liu Y, Cheung S, Chan RC, Inciardi JF, Cheng AF, Gastrointest Endosc., 53, 431 (2001)

[27] Unger F, Westedt U, Hanefeld P, Wombacher R, Zimmermann S, Greiner A, Ausborn M, Kissel T, J. Control. Release, 117, 312 (2007)

[28] Lee SY, Bae IH, Park DS, Jang EJ, Shim JW, Lim KS, Park JK, Sim DS, Jeong MH, J. Biomed. Mater. Res. A, 105(1), 1002 (2017)