Membrane-based separations are becoming popular and membrane technology using reverse osmosis (RO) is long established as a large-scale industrial membrane process for desalination. Membranes need to be managed after its life cycle. Advanced oxidation processes (AOPs) for aqueous organic waste handling are known and are being practiced in industries. The effectiveness of various AOPs based on hydrothermal process techniques to liquefy and depolymerize the different components of the thin-film composite membranes has been discussed in this paper. This helps in conversion of bulky molecules into smaller ones and facilitates toward meeting environmental regulations. For economic and environmental reasons, other reuse, recycle, and disposal options must be considered and investigated. The effect of factors such as temperature, duration, radiation, and concentration of reaction media on liquefaction/depolymerization of different components of spent RO module has been presented.