Fouling of the catalyst layer in the alcohol fuel cells is a challenge, which reduces the catalyst performance and lifetime. In this study for the first time, the effect of zinc oxide (ZnO) as an antifouling agent for ethanol oxidation reaction (EOR) in alkaline media on the palladium-silver bimetallic catalyst is investigated. ZnO rods is electrochemically deposited at a short time and at a constant current on the carbon cloth (CC) substrate and then palladium and silver are electrodeposited simultaneously at room temperature and at a short time on the ZnO rods (AgPd/ZnO/CC). Cyclic voltammetry tests show the ethanol oxidation on the proposed anode is more complete and the CO-stripping experiments show ZnO can reduce the catalyst layer poisoning considerably. Also, the onset potential and ethanol oxidation peak position are significantly more negative than AgPd/CC, which means the EOR is easier on the proposed electrode. (C) 2019 The Electrochemical Society.