Fossil fuel oxy-combustion is an emerging technology where the habitual nitrogen diluent is replaced by high-pressure supercritical CO2 (sCO(2)), which increases the efficiency of energy conversion. In this study, the chemical kinetics of the combustion reaction C2H6 (sic) CH3 + CH3 in the sCO(2) environment is predicted at 30-1000 atm and 1000-2000 K. We adopt a multiscale approach, where the reactive complex is treated quantum mechanically in rigid rotor/harmonic oscillator approximation, while environment effects at different densities are taken into account by the potential of mean force, produced with classical molecular dynamics (MD). Here, we used boxed MD, where enhanced sampling of infrequent events of barrier crossing is accomplished without application of the bias potential. The multistate empirical valence bond model is applied to describe free radical formation accurately at the cost of the classical force field. Predicted rates at low densities agree well with the literature data. Rate constants at 300 atm are 2.41 x 10(14)T(-0.20) exp(-77.03 kcal/mol/RT) 1/s for ethane dissociation and 8.44 X 10(-19)T(1.42) exp(19.89 kcal/mol/RT) cm3/molecule/s for methyl-methyl recombination.