A super activated carbon (SAC) was produced by KOH-activation of a biomass waste for paracetamol (PCT) adsorption from aqueous solution and for adsorption-thermal regeneration cycles. The SAC and the regenerated SAC after five adsorption-regeneration cycles (RSAC-5th) were fully characterized by several techniques. The N-2 physisorption showed that the S-BET values of the SAC and RSAC-5th are remarkably different, being 2794 m(2) g(-1) and 889 m(2) g(-1), respectively. The XPS analysis demonstrated that the SAC surface is composed by oxygen containing-groups, whilst the RSAC-5th also presents nitrogen ones, provenient from the PCT molecules. The adsorption studies revealed that the maximum adsorption capacity (Q(m)) for the SAC (356.22 mg g(-1)) is higher than that for RSAC-5th (113.69 mg g(-1)). Also, the results demonstrated that the PCT adsorption is governed by both physisorption and chemisorption and the ab initio calculations showed the chemisorption mainly occurs in carboxylic groups.