Applying a HiGee reactor for H2S removal with solid sulfur generation by a chelated iron solution offers an economical way to exploit offshore natural gas. However, the high H2S removal efficiency with the blockage problem caused by sulfur deposited inside the rotor of HiGee reactor needs to be taken into consideration. In this work, a novel HiGee reactor, called a rotating packed bed (RPB) reactor with mesh-pin rotor (MPR), was applied for H2S removal with the purpose of relieving blockage. Results show that the H2S removal efficiency of the RPB reactor with MPR was greater than 99.85% at the inlet H2S concentration of 8000 ppm. A mass increase ratio was proposed to evaluate the performance of relieving blockage. Compared with the full wire mesh packing rotor, the RPB reactor with MPR has high H2S removal efficiency and demonstrates excellent performance of relieving blockage, displaying considerable application prospects.