In this study, we present the modeling of the hydrate dissociation pressures for methane, ethane, and propane in the presence of NaCl, KCl, and CaCl2 aqueous solutions using a modified equation of state for aqueous electrolyte solutions with partial ionization (AES-PI) coupled with the van der Waals-Platteeuw theory. The proposed thermodynamic model includes a linear correlation for describing the ionic hydration process as a function of the pressure and molality. The proposed approach is capable of representing the inhibition effect at different salt concentrations. The results showed an excellent agreement between the experimental data and the calculated values at different conditions typical of the deepwater environment.