Platinum-based catalysts are promising materials for the propane dehydrogenation (PDH). The Pt sintering and carbon deposition are still the urgent problems to be solved in this system. This paper investigates an investigation of effect of perovskite-type oxide (PTO) lattice confinement on the catalytic performance of Zn(Ni)TiO3/SiO2 supported Pt-Ni bimetallic catalysts for PDH. The supported PTO precursors and derived catalysts were analyzed by XRD, H-2-TPR, TEM, XPS and TG techniques. The results show that the Pt-Ni alloy nanoparticles (NPs) are formed and highly dispersed on Zn(Ni)TiO3/SiO2. The optimized Pt loading amount is 0.4 wt%, which enhances the propane conversion to 38.6% and propene selectivity of 96.6%. The superior catalytic performance and anti-sintering and carbon deposition ability of Pt-Ni/Zn(Ni)TiO3/SiO2 catalyst are ascribed to the addition of appropriate Pt amount, which is beneficial to being confined in PTO lattice and building the abundant Pt-Ni alloy sites and moderate Pt-Ni interaction. The unconfined Pt coming from excessive Pt addition and impregnated Pt can result in Pt sintering and carbon formation. [GRAPHICS] .