In this study, we reported a simple but effective ultrasound-driven route to form and deposit MoS2 onto CdS substrate, which was carried by ultrasonic irradiation in an ultrasonic cleaning bath. The ultrasonic irradiation of a suspension of CdS nanowires and (NH4)(2)MoS4 in an aqueous solution of ethanol for 30 min yielded a MoS2 nanosheets-deposited CdS composite (MoS2/CdS). The resulting MoS2/CdS has been shown to significantly enhance the photocatalytic performance for H-2 evolution compared to pure CdS. Various characterization results reveal that the MoS2 nanosheets deposited on CdS by the ultrasound-driven route are short-range shaped, less ordered, few-layered, and close in contact with CdS, which are responsible for the enhanced H-2 evolution performance. We believe that the present work opens up a new avenue for the fabrication of MoS2/sulphide used for efficient photocatalytic H-2 evolution.