Effect of a surface-active agent on nucleation kinetics in ultrasound-assisted crystallization of paracetamol

Wang-Soo Kim; Dong-Woo Kim; Kee-Kahb Koo

Journal of Industrial and Engineering Chemistry, Vol.77, 441-448, September, 2019

DOI10.1016/j.jiec.2019.05.009 Export Citation

Effect of a surface-active agent on nucleation kinetics in ultrasound-assisted crystallization of paracetamol

Wang-Soo Kim, Dong-Woo Kim, and Kee-Kahb Koo^†

Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04107, Republic of Korea

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To reduce the size of paracetamol crystals for enhancement of the dissolution property, a crystallization process involving sonication to supersaturated paracetamol solution obtained by rapid cooling was proposed. It was found that when polyvinylpyrrolidone, a surface-active agent that exerts an inhibitory effect on coalescence of cavitation bubbles generated by sonication, was added, the kinetic parameter of classical nucleation theory increased remarkably. The average size of the paracetamol crystals obtained using the proposed process, which inhibited agglomeration, was about 3 μm with a narrow size distribution, where these particles are much smaller than the agglomerates (40-50 μm) obtained by agitation alone.

Keywords:Paracetamol;Sonocrystallization;Nucleation kinetics;Dissolution rate

[References]

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Dokoumetzidis A, Macheras P, Int. J. Pharm., 321, 1 (2006)
Murdande SB, Shah DA, Dave RH, J. Pharm. Sci., 104, 2094 (2015)
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O’Mahony M, Leung AK, Ferguson S, Trout BL, Myerson AS, Org. Process Res. Dev., 19, 1109 (2015)
Granberg RA, Rasmuson AC, J. Chem. Eng. Data, 44, 1391 (1999)
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Vancleef A, Seurs S, Jordens J, Gerven TV, Thomassen LCJ, Braeken L, Crystals, 8, 326 (2018)
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Xiao Y, Tang SK, Hao H, Davey RJ, Vetter T, Cryst. Growth Des., 17, 2852 (2017)
Wen H, Morris KR, Park K, J. Pharm. Sci., 94, 2166 (2005)
Anwar J, Boateng PK, Tamaki R, Odedra S, Angew. Chem., 121, 1624 (2009)
Kim JW, Park JH, Shim HM, Koo KK, Cryst. Growth Des., 13, 4688 (2013)
Miyazaki T, Yoshioka S, Aso Y, Kojima S, J. Pharm. Sci., 93, 2710 (2004)
Kordylla A, Krawczyk T, Tumakaka F, Schembecker G, Chem. Eng. Sci., 64(8), 1635 (2009)
Guo Z, Jones AG, Hao H, Patel B, Li N, J. Appl. Phys., 101, 054907 (2007)

[Referenced By]

[1] Variankaval N, Cote AS, Doherty MF, AIChE J., 54(7), 1682 (2008)

[2] Dokoumetzidis A, Macheras P, Int. J. Pharm., 321, 1 (2006)

[3] Murdande SB, Shah DA, Dave RH, J. Pharm. Sci., 104, 2094 (2015)

[4] Jacobs C, Kayser O, Muller RH, Int. J. Pharm., 196, 161 (2000)

[5] Lee J, Choi JY, Park CH, Int. J. Pharm., 355, 328 (2008)

[6] Shi LJ, Plumley CJ, Berkland C, Langmuir, 23(22), 10897 (2007)

[7] Radacsi N, Ambrus R, Szunyogh T, Szabo-Revesz P, Stankiewicz A, van der Heijden A, ter Horst JH, Cryst. Growth Des., 12, 3514 (2012)

[8] O’Mahony M, Leung AK, Ferguson S, Trout BL, Myerson AS, Org. Process Res. Dev., 19, 1109 (2015)

[9] Granberg RA, Rasmuson AC, J. Chem. Eng. Data, 44, 1391 (1999)

[10] Gielen B, Kusters P, Jordens J, Thomassen LCJ, Van Gerven T, Braeken L, Chem. Eng. Process., 114, 55 (2017)

[11] Gielen B, Claes T, Janssens J, Jordens J, Thomassen LCJ, Van Gerven T, Braeken L, Chem. Eng. Technol., 40(7), 1300 (2017)

[12] Vancleef A, Seurs S, Jordens J, Gerven TV, Thomassen LCJ, Braeken L, Crystals, 8, 326 (2018)

[13] Bhangu SK, Ashokkumar M, Lee J, Cryst. Growth Des., 16, 1934 (2016)

[14] Tronson R, Tchea MF, Ashokkumar M, Grieser F, J. Phys. Chem. B, 116(46), 13806 (2012)

[15] Jordens J, Coker ND, Gielen B, Gerven TV, Breaken L, Ultrason. Sonochem., 26, 64 (2015)

[16] Jiang S, ter Horst JH, Cryst. Growth Des., 11, 256 (2011)

[17] Xiao Y, Tang SK, Hao H, Davey RJ, Vetter T, Cryst. Growth Des., 17, 2852 (2017)

[18] Wen H, Morris KR, Park K, J. Pharm. Sci., 94, 2166 (2005)

[19] Anwar J, Boateng PK, Tamaki R, Odedra S, Angew. Chem., 121, 1624 (2009)

[20] Kim JW, Park JH, Shim HM, Koo KK, Cryst. Growth Des., 13, 4688 (2013)

[21] Miyazaki T, Yoshioka S, Aso Y, Kojima S, J. Pharm. Sci., 93, 2710 (2004)

[22] Kordylla A, Krawczyk T, Tumakaka F, Schembecker G, Chem. Eng. Sci., 64(8), 1635 (2009)

[23] Guo Z, Jones AG, Hao H, Patel B, Li N, J. Appl. Phys., 101, 054907 (2007)