화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.76, 173-180, August, 2019
DOI10.1016/j.jiec.2019.03.036  Export Citation
In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
Sang Jin Lee1, Han-Jun Kim2, Min Heo1, Hye-Rim Lee2, Eun-Ji Choi2, Hyosung Kim2, Donghyun Lee1, Rui L. Reis1, 3, Sun Hee Do2, †, and Il Keun Kwon1, †
  • 1Department of Dental Materials, School of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea
  • 2Department of Clinical Pathology, College of Veterinary Medicine, Konkuk University, 120, Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea
  • 33B’s Research Group – Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University Minho, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, GMR 4805-017, Portugal
E-mail:,
In this study, we manufactured various ratios of polycaprolactone (PCL)/gelatin (GE) highly aligned electrospun nanofibrous scaffolds (ENs) to investigate the effects of polymer ratio on tenogenic differentiation activity. For biological assessments, the cell proliferation rate was optimal in the PCL/GE (9:1) group. Interestingly, however, the tenogenic differentiation rate was best for the PCL/GE (7:3) group. From our outcomes, we established that a poly-blending mix of PCL/GE (7:3) is a promising ratio for tenogenic differentiation. Thus, our findings may provide for an effective mesh to promote tenogenic differentiation of ENs in future tendon tissue engineering applications.
Keywords:Electrospinning;Polycaprolactone;Gelatin;Highly aligned nanofiber;Tendon tissue engineering applications
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