Thin films were deposited by plasma co-polymerization of 2-isopropenyl-2-oxazoline and 1-octene, varying the total monomers flow rate and the 1-octene percentage in the mixture. The coatings wettability was evaluated by water contact angle measurements, while their stability was investigated by immersion in Phosphate Buffer Saline at 37 degrees C. The chemical characterization of the coatings, performed by means of Attenuated Total Reflectance Fourier Transform Infrared spectroscopy and by reaction with poly(acrylic acid), assessed a partial retention of the reactive oxazoline ring, as already observed for plasma polymerization of several oxazoline monomers alone. However, the addition of 1-octene had significant effects on the coating stability and on the surface availability of reactive oxazoline rings. Compared to those obtained by plasma polymerization of 2-isopropenyl-2-oxazoline alone, this coatings exhibited higher stability in aqueous environments but lower reactivity towards carboxylic acid groups.