A novel reverse electrodialysis enhanced photocatalytic fuel cell (PREC)-Fenton system is established for advanced treatment of coal gasification wastewater. Results indicate the reverse electrodialysis (RED) stack is crucial to achieve higher electricity production and H2O2 generation. Operational parameters including salinity gradient, air flow rate, solutions flow rate and pH are investigated. The optimal H2O2 production and wastewater treatment are observed at salinity ratio of 100, air flow rate of 16 mL/min, solutions flow rate of 2.0 mL/min and a broaden pH of 2-7. A high coulombic efficiency of 59.6% and cathodic efficiency of 51% is obtained, while the COD, total phenol and NH4+ -N removal reach 92.4%, 86.1% and 77.3%. Moverover, the system requires much lower energy consumption of 26.4 kWh/(kg.TOC). The PREC-Fenton system is a more economical and efficient candidate for energy recovery and wastewater treatment.