Cemented paste backfill (CPB) plays a vital role in mineral engineering and understanding the cement hydration is crucial for its successful application. As an important constituent in ordinary Portland cement (5-15 wt%), ferrite is heavily used in CPB without being fully demonstrated due to its composition complexity. In this paper, the structural and electronic properties of Ca2Fe2O5 (C2F), Ca2AlFeO5 (C(4)AF) and Ca2Al2O5 (C(2)A) were investigated using first-principles calculations. The results indicated that lattice parameters and bond length decreased with increasing substitution of the smaller Al3+ for the larger Fe3+. The chemical reactivity of the unit cell was derived mainly from O 2p, Fe 3p, Fe 3d, and Al 3p orbitals. The O atoms were prone to electrophilic attack with cations such as H+. In contrast, the Fe/Al atoms were prone to nucleophilic attack with anions such as OH- and the Fe atoms were more reactive than the Al atoms. This study provides new insight into the structural and electronic properties of ferrite at the atomic level, which will provide a better understanding of cement hydration and promote the application of CPB.