In this study, a two-step synthesis route combining an electrospinning with a precipitation process was used to prepare one dimensional In2O3/In2TiO5 nanobelts. The obtained In2O3/In2TiO5 nanobelts were characterized with XRD, SEM, EDS, UV-vis DRS and N-2 adsorption-desorption isotherms. Effects of the mole ratios of In2O3 to In2TiO5 on the photocatalytic activity of photocatalyst were investigated using rhodamine B (RhB) as a model pollutant. Results showed that In2O3/In2TiO5 nanobelts with the mole ratio of 1-10 exhibited the highest photocatalytic activity under xenon lamp (150 W) irradiation. The degradation rate of RhB reached 97.1% in 120 min, and the photocatalytic degradation followed the first order kinetic model. Furthermore, the skeleton of levofloxacin (LEV) was completely destroyed after irradiation for 60 min. The recycling tests confirmed that the photocatalytic activity was still above 85% after 5 cycles. This proved that In2O3/In2TiO5 not only had an excellent visible-light-driven photocatalytic activity, but also could be used in organic dye removal and antibiotics wastewater treatment.