A sensitive and simple electrochemical sensor for determination of norepinephrine (NE) was developed. The electrode (ERG-UiO-67-bpy/GCE) was fabricated by modifying the glassy carbon electrode with a Zr (IV) metal-organic framework (MOF) with 2,2'-bipyridyl-5,5'-dicarboxylate (UiO-67-bpy) and graphene oxide (GO), followed by electrochemical reduction of GO to ERG (electrochemically reduced graphene). The ERG and UiO-67-bpy components of the composite electrode show a synergic electrocatalytic effect, leading to much enhanced voltammetric response to the oxidation of NE. Comparative studies indicate that the hydrogen bonds between the bipyridyl moiety of the MOF and the 2-aminoethanol moiety of NE play an important role in promoting electron transfer on the electrode surface. Differential pulse voltammetry using the composite electrode shows a wide linear-response concentration range with a submicromolar detection limit of 0.026 mu M. The sensor shows good reproducibility and stability and also be used for sensitive simultaneous detection of NE and uric acid. (C) 2019 The Electrochemical Society.