The solubility of isomaltulose in five monosolvents (water, methanol, ethanol, isopropanol, and acetone) and four different binary solvents (water + methanol, water + ethanol, water + isopropanol, and water + acetone) was measured by a gravimetric method at temperatures ranging from (283.15 to 323.15) K. Results showed that the solubility of isomaltulose increased with increasing temperature. The order of isomaltulose solubility in these selected pure solvents at a given temperature was water > methanol > ethanol > isopropanol > acetone. In water + acetone solvent system, the solubility of solute just increased with increasing water mole fraction. In water + alcohol solvent systems, the minimum solubility values were achieved at a certain solvent composition because of the influence of polarity and hydrogen bond. The Apelblat model, the CNIBS/R-K model, and the modified version of the Jouyban-Acree model (the Apel-JA model) were used to correlate the experimental data, and the results indicated that those models were all suitable to correlate the solubility results.