This paper focuses on optimizing the hydrogen TMI (timed manifold injection) system through valve lift law and hydrogen injection parameters (pressure, injection inclination and timing) in order to prevent backfire phenomena and improve the volumetric efficiency and mixture formation quality of a dual fuel diesel engine operating at high load and high hydrogen energy share. This was achieved through a numerical simulation using CFD code ANSYS Fluent, developed for a single cylinder hydrogen-diesel dual fuel engine, at constant engine speed of 1500 rpm, 90% of load and 42.5% hydrogen energy share. The developed tool was validated using experimental data. As a results, the operating conditions of maximum valve lift = 10.60 mm and inlet valve closing = 30 degrees CA ABDC (MVL10 IVC30) prevent the engine from backfire and pre-ignition, and ensure a high volumetric efficiency. Moreover, a hydrogen start of injection of 60 degrees CA ATDC (HSOI60) is appropriate to provide a pre-cooling effect and thus, reduce the pre-ignition sources and helps to quench any hot residual combustion products. While, the hydrogen injection pressure of 2.7 bar and an inclination of 60 degrees, stimulate a better quality of hydrogen-air mixture. Afterwards, a comparison between combustion characteristics of the optimized hydrogen-diesel dual fuel mode and the baseline (diesel mode) was conducted. The result was, under dual fuel mode there is an increase in combustion characteristics and NOx emissions as well as a decrease in CO2 emissions. For further improvement of dual fuel mode, retarding diesel start of injection (DSOI) strategy was used. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.