In this study, the simultaneous use of nanofluid and phase changing material as a coolant for photovoltaic fluid collector system and its effects are investigated experimentally. Two types of nanofluid are taken for the consideration, that is, ZnO and CuO, which are water-based fluid. The experiments are performed in five different types of photovoltaic thermal system conventional: PT, PVT (ZnO), PVT (CuO), PCM medium (PVT/PCM/ZnO), and PCM medium (PVT/PCM/CuO). The results are obtained for surface temperature, energy, and thermal efficiency, and it is compared with each other. Further, the effect of the nanofluid as the effective alternative for pure deionized water is measured. From the results, it is evident that the PVT/PCM/CuO system minted 15% high electric output compared with convention module. Furthermore, the addition of the CuO nanofluid increases the thermal output significantly up to 8% for PVT and 12% for PCM without energy consumption. It also found that the nanofluid increases the overall energy efficiency of the system compared with convention PV.