The organic solvent forward osmosis (OSFO) process suffers from certain drawbacks, such as relatively low solvent flux. One strategy to overcome the relatively low solvent flux of OSFO is to utilize an external hydraulic pressure, on top of the osmotic pressure difference across a membrane, to enhance the solvent transport through the membrane. Thus, organic solvent pressure assisted osmosis (OSPAO) has been proposed and demonstrated in this study to effectively recover organic solvents from pharmaceutical products. The OSPAO process was conducted using various solvents including ethanol, IPA, and hexane, with different draw solutes, such as lithium chloride (LiCl) and methyl palmitate. Experimental results show that the solvent flux can be significantly enhanced, while the reverse solute flux (RSF) is slightly reduced with an increase in applied hydraulic pressure from 0 to 1 bar. However, the enhancement in solvent flux by the external hydraulic pressure reduces as the draw solution concentration increases. Hence, it is vital to balance the effects from the draw solution concentration and the applied pressure in OSPAO processes. In addition, OSPAO exhibits impressive rejections of >99% when recovering organic solvents from feed solutions containing different solutes in the range of 100010 000 ppm. However, a relatively low hydraulic pressure is recommended to maintain the high rejection when the feed concentration is as high as 20 wt %. In summary, the significantly enhanced solvent flux and the well-maintained high rejection of OSPAO make it an extremely attractive technology for practical solvent recovery in the pharmaceutical industry.